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Anal Biochem 1983

Studies evaluating the gut microbiota in NHE3-knock-out (NH3 / ) mice have shown a shift in the bacteria phyla with contraction of Firmicutes and expansion of Bacteroidetes along the gastrointestinal tract (terminal ileum, cecum, and distal colon) in NHE3 / compared to wild type ( / may play a role in reducing the Firmicutes/Bacteroidetes ratio, hence TMA and consequently TMAO production (Romano et al., 2015

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